Martin Henry Dawson, the born subordinate.

He had a number of life-changing ideas but he was too cautious and too polite to go all out in proclaiming them and his colleagues and opponents knew it.

In a metaphorical sense, he was the proverbial 'coward of the county' .

I don't think he disobeyed but one order in his entire life.

But when he did.... our whole world changed for the better, forever.

@MOgoesPO

We agree WHEN Mo started going PO, but not necessarily why

                  Martin Henry Dawson , on enlistment, 1915

My partner, Rebecca, has tried to explain the meaning behind the title of my latest blog "MO goes PO" .

All I can add is that there is overwhelming agreement that the Mo-to-Po revolution began fairly abruptly, in 1945.

You remember 1945, the end of 'double-u, double-u, two' , the so called last good war and the last good generation.

Few people have given a good account why PoMo began then, AND in the nations of the moral victors.

If the good guys are just won the war against the bad guys, why were the good guys leading the way in uneasily evaluating their own values ?

I hope "MO goes PO" succeeds in telling us why....

@ArcadianRecord

This is my new blog for my MARTIN HENRY DAWSON project

I will post the finished segments ( albeit not likely in their proper chronological sequence) here, one week after the 'final' version of each segment has had a chance to pass my 'wiggle test'.

That is to say, I will print out a reduced size, B&W 'final version' copy on my computer printer and see how it reads on paper, after it has been lying around my house a day or two.

For sometimes you catch things you didn't when the segment was on the computer screen, no matter how often you re-read and re-edited it.

In time, I will also put each of these segments in my 'MO goes PO'  public archives - my 16 GOOGLE SITES websites.

But this time, they will be in their intended chronological order, leaving blanks for the segments not yet published.

One GOOGLE SITES website for each of 15 Scenes (in three Acts)  --- plus one for the author's Afterword.

No more than 26 segments maximum per Scene - hopefully not that many ! - so I can label them from A to Z.

So their numbering will be labelled 3c and 16j etc , indicating that the first is the third segment of Act I, Scene 3, while the other is the tenth segment in the author's Afterword.

Think of it as a sort of Play or Musical covering six years (exactly - September 2nd 1939 to September 2 1945) in three hours...

I will reserve my right totally, to revise/ revise/ revise each 'final' segment - but you will at least be able to follow the revisions publicly.

@mogoespo

Three classic examples of HGT are a key motif in lifework of Martin Henry Dawson

Martin Henry Dawson 1942 - suffering from terminal Myastenia Gravis

From the 1920s till the 1950s, Martin Henry Dawson published more articles and made more public presentations on Horizontal Gene Transfer (HGT) than any other scientist - in fact more than all of them combined -- quite simply 'No Dawson, No DNA'.

But he died, tragically young, in 1945, though not before seeing through three different projects that involved HGT - though he was probably only convinced that HGT was involved in the first.

Not to say he didn't have strong personal suspicions in the other two cases - but it seemed too wild to be prudent to talk about publicly.

S. pneumoniae are detected and eaten by our adaptive immune system based on the the more than 90 different goo capsules that surround each of the 90 different strains of s. pneumoniae bacteria.

One way to survive being eaten is to quickly and randomly change your 'cap' - or not wear one at all.

Dawson with Sia and Warbasse, between 1928 - 1933, showed this to be done by biofilm colonies (it can only happen in close-quartered biofilm colonies, not in widespread thin populations of planktonic bacteria) by the bacteria taking a vote by exchanging chemical emails (Quorum-sensing/ aka Q-sensing) and then agreeing to exchange the DNA genes needed to change capsules.

By 1934, Dawson had become interested in the capsules of s. pyrogenes, mostly because they were NOT of interest to our adaptive immune system !

He discovered this is because they were made up of something the human body needs to use like wampum - Hyaluronan - the same stuff injected into wrinkles to restore their cosmetic youthfulness !

Our immune cells see this stuff in use everywhere in the body in dozens of different situations - it screams "self" like nothing else - so they leave it alone.

But only 6 species of bacteria make this goo - it is an energy intensive process and if it didn't get used to protect our commensal bacteria from attack of the white blood cells whenever they venture into the blood stream, it would only become a fatal burden to make.

Evidence is strong that these few bacteria borrowed the basic technique & the genes to make it from some animal host a long time ago (HGT between animals and bacteria does occur) and adapted it to suit themselves.

Since the s. pyrogenes are our single deadliest killer bacteria and this capsule a crucial means for them being able to do their work inside us and survive, this shows again what HGT means to us, in highly practical terms - it can kill us.

Finally, Dawson successfully cured the deadliest common heart disease of his day - SBE, endocarditis caused by green strep , s. viridans - normally harmless long term residents of our mouth.

He did so, starting 70 years ago this October 16th, with penicillin.

Penicillin is merely the best known of a very large family of antibiotics that still are our major life-savers - the beta lactams.

Most are made by bacteria and effectively force other bacteria to give the producers a wide berth.

Because only a few fungi make beta lactams compared to many bacteria, because the fungi's penicillin gene cluster looks to be so close to all the bacteria beta lactam creating structures, and because bacteria were here well before fungi, most experts feel that HGT was the means for the penicillin-making genes going from bacteria to fungi and then into us as an life-saving medicine.

But bacteria are mostly resistant to penicillin you say.

HGT again - the cluster of genes of resistance to penicillin existed long before Dawson put penicillin to work as an antibiotic in 1940.

When it became needed for bacteria to survive, they rapidly spreading it about around the world - by HGT ....

@arcadianrecord

Martin Henry Dawson's lifework- Lobar Pneumonia,Rheumatic Fever,SBE : when hosts overreact

MARTIN HENRY DAWSON 1896-1945

When harmless tiny bacteria called S. pneumococcus living peacefully in your throat get blown the equivalent of 1000 miles deep into our lungs - they panic.

Who won't?

More fatally, so does our body's immune system.

Like a latter day 'Bomber Harris', the immune system 'area bombs' our lungs - too often the collateral damage is us.

S. pyrogenes bacteria is so used to surviving in us, its only home on Earth, that it begins to look like us - and when our immune system overreacts to a case of strep throat, it might start attacking our heart tissue instead of the long since defeated strep throat : the result is often- fatal acute Rheumatic fever.

Lucky you, you've survived a couple of attacks of Rheumatic fever - except for a scared

heart valve ---- a valve messed up by your own immune system.

Now you've neglected your teeth and gums a little and the gums tend to bleed when you do brush them.

This allows some harmless S. viridans (green strep - the bacteria that makes unbrushed teeth look ,well, sort of green - not actually the reason they are called green strep but a colorful coincidence !) to get into the blood stream and start whirling around your body much faster than the Space Shuttle does with us.

Naturally the green strep panic and start looking for a new safe home before giant white blood cells swallow them for dinner.

All these bacteria can't move - they are basically tiny blogs of jelly who can stick to particular types of human cells, if they have the right kind of adhesive on their surface for that kind of cell and they happen to bump into it and not the wrong sort of cell.

Its all a lot of hapstance.

Hardly your usual predators, right??

Usually, the green strep gets eaten before it makes that safe haven. But for people with scared heart valves, the scar tissue (produced by our immune system - remember ?) is

just the sort of thing that could be that safe haven.

If they make it into these scar areas' depths, while whirling past at space-travel-like speeds, they attach themselves to the scars.

The immune system reacts by creating more scar tissue, which inadvertently prevents white blood cells from getting in and at the green strep.

The green strep start re-creating dental plaque (and tartar) right on the heart valve - taking a biofilm meant for our mouth and teeth and replicating in not too dissimilar circumstances at the heart valve.

A normal biofilm colony eventually lets loose bits of itself in the liquid swirling over it to form mini colonies elsewhere - the green strep on the heart valve do the same.

We call those particular mini colonies 'embolus showers' and if and when they reach a heart/ lung or brain blood vessel with a restricted passage, they will block it and kill us.

Explaining and preventing or curing these three serious/common/fatal diseases was to be Martin Henry Dawson's lifework.

In a sense, he succeeded well beyond his expectations and changed our world , for the better, for ever.

All three dieases are the unexpected side effects of us and our fellow commensals scrambling to adjust to a micro change in our body's environment.

Just as global warming today is making all of the world's commensals scramble to adjust to a macro change in our environment.....

@arcadianrecord

Martin Henry Dawson - the Commensal Doctor

Martin Henry Dawson 1896-1945

S. Pyrogenes/GAS Strep/Hemolytic Strep - whatever you call it, this bacteria is usually regarded as the single deadliest pathogen we humans face over our lifetime.

This is because the list of fatal diseases it is implicated in runs into pages and can involve almost every part of the body,in any age group , in any part of the world.

Paradoxically, S. pyrogenes is only found in humans - it exists no where else - and usually lives peacefully - more or less - in our throats, as it has for millions of years.

It hoes a narrow row - but it hoes it deep and long - it can outwit anything our body or our mind's invention can put up to remove it, as it struggles to get by.

Martin Henry Dawson spent 20 years (all of his tragically short life as a scientific researcher) also hoeing a narrow row, deep and long.

He tried always to remain focussed on one area: the consequences for both of us, human and oral strep, of co-sharing one body so intimately all of our collective life.

A rarity in his day, he tried ,as a medical scientist, to see our body from its bacterial flora's point of view: to study how they wiggled and twirled -genetically- as they struggled to survive in our body's hostile environment.

Some bacteria is only 175 billionths of a metre "tall" - that means the body of an adult male is exactly as big to them as our Earth is to us - they aren't in any way aware they are 'invading' a body - they see us only as a vast hostile & lush world.

Early humans also didn't know they lived in a tiny part of a big sphere of rock that in turn only made up a tiny part of the entire universe - they saw no further than area immediately around them.

It is always worth recalling that we are actually 90% them and 10% us, if you count the number of bacterial cells on us, versus all the cells of our internal organs.

Without any of us, they would quickly die in hours - without them, we would die in a few months.

We must co-exist together, diners at a common table - commensals as a biologist or theologian would say.

Dawson never used that term as far as I know ( he died, after all, in 1945, before the word came into common use in medical or religious circles), but he lived his life as if it was the central core of his being as a scientist.....

@arcadianrecord

If History is written by the Victor, then the history of World War Two has never been written...

... because the victor can neither read or write.

But histories can be written that reflect the point of view of the victor and these are now being written,albeit a bit late - sometimes more than 75 years after the events they describe.

I can recommend Allan Tooze (WAGES OF DESTRUCTION) and Mark Mazower (HITLER'S EMPIRE) as a good places to start.

I think - and I hope -that my account of The Manhattan Pilot will be one of those victor - oriented histories.

@arcadianrecord